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HCV Care & Guidance
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Chapter 1
Getting Ready for Direct-Acting Antiviral (DAA) Therapy

Chapter 2
What You Need to Know About the New Direct-Acting Antiviral (DAA) Regimens

Chapter 3
Hematologic Adverse Effects

Chapter 4
Dermatologic Adverse Effects

Chapter 5
Gastrointestinal Adverse Effects

Chapter 6
Neuropsychiatric Adverse Effects

Chapter 7
Understanding Drug-Drug Interactions in this New Triple-Therapy Era

Chapter 8
Treating HCV in Special Populations

Chapter 9
Predictors of Response

Chapter 10
Treating Hepatitis C in Patients with Cirrhosis

Chapter 11
Anti-Hepatitis C Triple Therapy Update

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Chapter 3 – Hematologic Adverse Effects

Contributing Editor
Cheryl D. Levine Cheryl D. Levine, PhD, FNP
Clinical Research Director
Texas Clinical Research Institute
Arlington, Texas

Contributing Faculty
Sherilyn C. Brinkley Sherilyn C. Brinkley, MSN, CRNP
Nurse Practitioner/ Program Manager
Infectious Disease Department
Johns Hopkins University
Baltimore, Maryland

Activity Goal
The goal of this activity is to address the need of nurse practitioners and physician assistants for information and practical instruction regarding new direct-acting antiviral (DAA) therapies for hepatitis C and their integration into clinical practice.

Target Audience
This CME/CE activity has been designed for nurses, nurse practitioners, physician assistants, hepatologists, gastroenterologists, infectious disease specialists, and pharmacists involved in the care of patients with HCV or those at risk of acquiring the infection.

Learning Objective
Evaluate hematologic adverse effects associated with direct-acting antiviral anti-HCV therapies in order to formulate effective preventive and management strategies in patients with chronic hepatitis C.


CME Information: Physicians
Statement of Accreditation
Projects In Knowledge® is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

Projects In Knowledge® designates this enduring material for a maximum of 2 AMA PRA Category 1 Credit(s). Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CE Information: Nurses
Projects In Knowledge® (PIK) is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center's Commission on Accreditation.

Upon completion of this course, participants will be awarded 1.00 nursing contact hour(s).

Joint Accreditation Nursing Provider Number: 4008235

DISCLAIMER: Accreditation refers to educational content only and does not imply ANCC, or PIK endorsement of any commercial product or service.


Disclosure Information
The Disclosure Policy of Projects In Knowledge requires that presenters comply with the Standards for Commercial Support. All faculty are required to disclose any personal interest or relationship they or their spouse/partner have with the supporters of this activity or any commercial interest that is discussed in their presentation. Any discussions of unlabeled/unapproved uses of drugs or devices will also be disclosed in the course materials. For complete prescribing information on the products discussed during this CME/CE activity, please see your current Physicians' Desk Reference (PDR).

Cheryl D. Levine, PhD, FNP, has received honoraria from Genentech Inc, Merck & Co., Inc, and Vertex Pharmaceuticals Incorporated; has received consulting fees from Vertex Pharmaceuticals Incorporated; and has conducted contracted research for Abbott, Achillion Pharmaceuticals, Inc, Boehringer-Ingelheim, Bristol-Myers Squibb Company, Genentech Inc, Gilead Sciences, Inhibitex, Inc, Medtronic, Novartis Pharmaceuticals Corporation, Pharmasset Pharmaceuticals Inc, Vertex Pharmaceuticals Incorporated, and ZymoGenetics.

Sherilyn C. Brinkley, MSN, CRNP, has received honoraria from Genentech Inc, Merck & Co., Inc, and Vertex Pharmaceuticals Incorporated; and has received consulting fees from Merck & Co., Inc, and Vertex Pharmaceuticals Incorporated.

Nancy J. Nordenson, MFA, MT (ASCP) has disclosed no significant relationships.

Peer Reviewer has disclosed no significant relationships.

Dorothy Caputo, MA, BSN, RN (lead nurse planner) has no significant relationships to disclose.
Bernadette Marie Makar, MSN, NP-C, APRN-C (nurse planner) has no significant relationships to disclose.

Projects In Knowledge’s staff members have no significant relationships to disclose.


Conflicts of interest are thoroughly vetted by the Executive Committee of Projects In Knowledge. All conflicts are resolved prior to the beginning of the activity by the Trust In Knowledge peer review process.

The opinions expressed in this activity are those of the faculty and do not necessarily reflect those of Projects In Knowledge.

This CME/CE activity is provided by Projects In Knowledge solely as an educational service. Specific patient care decisions are the responsibility of the clinician caring for the patient.

Contract for Mutual Responsibility in CME/CE
Projects In Knowledge has developed the contract to demonstrate our commitment to providing the highest quality professional education to clinicians, and to help clinicians set educational goals to challenge and enhance their learning experience.

For more information on the contract, click here

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Launch Activity

Projects In Knowledge®

Peer Reviewed

Vertex Pharmaceuticals Incorporated and Merck Co

Release Date: July 28, 2011.

Termination Date: July 27, 2013.

Estimated time for completion of this activity:
CME: 2.00 hours
CNE: 1.00 hour

CME/CE Instructions
To obtain CME/CE credit for this activity:
  1. Read the chapter carefully.
  2. Complete/submit the posttest and evaluation.
  3. Instantly access and print out your certificate.

There is no fee for this activity.

For questions about content or obtaining CME credit, please contact us.


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