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| Chapter 2 – Clinical Trial Design in Parkinson's Disease
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Editor-In-Chief |
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Robert A. Hauser, MD, MBA
Professor of Neurology,
Molecular Pharmacology
and Physiology
Department of Neurology
University of South Florida
Tampa, Florida
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Activity Goal
The goal of this CME/CE activity is to examine preclinical nonmotor features, disease modification trials, clinical disease progression, MAO-B inhibitors, and current strategies for treating and managing patients with Parkinson's disease.
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Target Audience
This CME/CE activity is designed for Parkinson’s disease physician specialists, community neurologists, Parkinson’s disease nurse specialists, and pharmacists.
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Learning Objectives
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Illustrate why slowing or halting the progression of PD would be an important addition to currently available symptomatic treatments. |
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Analyze the current state of biomarkers for neuronal degeneration in PD in order to interpret the results of clinical trials that used biomarkers as surrogate measures of neuroprotection in PD. |
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Evaluate advantages and disadvantages of delayed-start and washout trial designs in order to interpret the results of clinical trials that used these designs to assess neuroprotection in PD. |
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CME Information: Physicians
Statement of Accreditation
Projects In Knowledge® is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
Credit Designation
Projects In Knowledge® designates this enduring material for a maximum of 2.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
CE Information: Nurses
Projects In Knowledge® (PIK) is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center's Commission on Accreditation.
Projects In Knowledge is also an approved provider by the California Board of Registered Nursing, Provider Number CEP-15227.
Upon completion of this course, participants will be awarded 1.11 nursing contact hour(s).
DISCLAIMER: Accreditation refers to educational content only and does not imply ANCC, CBRN, or PIK endorsement of any commercial product or service.
CE Information: Pharmacists
Projects In Knowledge® is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education.
This program has been planned and implemented in accordance with the ACPE Criteria for Quality and Interpretive Guidelines. This chapter is worth up to 2.00 contact hours (0.2 CEUs). The ACPE Universal Activity Number assigned to this Application-type activity is 0052-0000-12-1735-H01-P.
Pharmacists should only claim credit commensurate with the extent of their participation in the activity.
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Disclosure Information
The Disclosure Policy of Projects In Knowledge requires that presenters comply with the Standards for Commercial Support. All faculty are required to disclose any personal interest or relationship they or their spouse/partner have with the supporters of this activity or any commercial interest that is discussed in their presentation. Any discussions of unlabeled/unapproved uses of drugs or devices will also be disclosed in the course materials. For complete prescribing information on the products discussed during this CME/CE activity, please see your current Physicians' Desk Reference (PDR).
Robert A. Hauser, MD, MBA, has received honoraria from Allergan Neuroscience, Biogen Idec, Boehringer Ingelheim, Embryon, GE Healthcare, Genzyme, GlaxoSmithKline, Impax, Ipsen Pharmaceuticals, Kyowa Pharmaceutical, Merck Serono international, Novartis Pharmaceuticals Corporation, Quintiles, Santhera, Schering Plough, Solvay Pharmaceuticals, Synosia Therapeutics, Teva Neurosciences, UCB, and Xenoport. Lauren A. Cerruto (medical writer), has no significant relationships to disclose. Peer Reviewer has disclosed no significant relationships. Dorothy Caputo, MA, BSN, RN (lead nurse planner) has no significant relationships to disclose. Bernadette Marie Makar, MSN, NP-C, APRN-C (nurse planner) has no significant relationships to disclose. Projects In Knowledge’s staff members have no significant relationships to disclose. top
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Conflicts of interest are thoroughly vetted by the Executive Committee of Projects In Knowledge. All conflicts are resolved prior to the beginning of the activity by the Trust In Knowledge peer review process.
The opinions expressed in this activity are those of the faculty and do not necessarily reflect those of Projects In Knowledge.
This CME/CE activity is provided by Projects In Knowledge solely as an educational service. Specific patient care decisions are the responsibility of the clinician caring for the patient.
Contract for Mutual Responsibility in CME/CE
Projects In Knowledge has developed the contract to demonstrate our commitment to providing the highest quality professional education to clinicians, and to help clinicians set educational goals to challenge and enhance their learning experience.
For more information on the contract, click here
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Projects In Knowledge is a registered trademark of Projects In Knowledge, Inc.
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These independent CME/CE activities are supported by an educational grant from Teva Neuroscience.

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Release Date: July 30, 2012.
Termination Date: July 29, 2013.
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Estimated time for completion of this activity: CME: 2.00 hours
CNE: 1.11 hours
CPE: 2.00 hours
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CME/CE Instructions
To obtain CME/CE credit for this activity:
- Read the chapter carefully.
- Complete/submit the posttest and evaluation.
- Instantly access and print out your certificate.
There is no fee for this activity.
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| For questions about content or obtaining CME credit, please contact us. |
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